The distribution and metabolism of lysergic acid diethylamide.
نویسندگان
چکیده
Although lysergic acid diethylamide (LSD), the hallucinogenic agent, has been the subject of numerous investigations, little is known about its biologic fate. In recent studies Boyd et al.’ and St011 el ~1.2 have examined the tissue distribution of CL4-labeled LSD in mice. Stoll and his co-workers2 have shown that the Cr4-labeled material measured in tissues included LSD, as well as transformation products of the drug. Lanz, Cerletti, and Roth1in3 have also measured the tissue levels of LSD in mice by the use of a bioassay procedure based on the antagonism of LSD to serotonin-induced contraction of the uterus of the rat. These investigators, however, did not show that possible biologically active transformation products of LSD were excluded from the assay procedure. The development of a specific and sensitive method for the estimation of LSD in biological materials has enabled us to study the tissue distribution, excretion, rate of biotransformation, and metabolism of the drug, as well as the subcellular processes involved in its transformation.
منابع مشابه
The effects of D-lysergic acid diethylamide on cerebral circulation and overall metabolism.
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Pharmacokinetics and Concentration-Effect Relationship of Oral LSD in Humans
BACKGROUND The pharmacokinetics of oral lysergic acid diethylamide are unknown despite its common recreational use and renewed interest in its use in psychiatric research and practice. METHODS We characterized the pharmacokinetic profile, pharmacokinetic-pharmacodynamic relationship, and urine recovery of lysergic acid diethylamide and its main metabolite after administration of a single oral...
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ورودعنوان ژورنال:
- Annals of the New York Academy of Sciences
دوره 66 3 شماره
صفحات -
تاریخ انتشار 1957